Rotavirus Nonstructural Protein 4 (NSP4)-Viral Enterotoxin with Multiple roles in Pathogenesis of Diarrhoea in Children
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منابع مشابه
Rotavirus Nonstructural Protein 4 (NSP4)-Viral Enterotoxin with Multiple roles in Pathogenesis of Diarrhoea in Children
Article history: Received on: 06/05/2015 Revised on: 24/05/2015 Accepted on: 14/07/2015 Available online: 27/07/2015 Nonstructural protein 4 (NSP4) of Rotavirus has been designated as the first viral enterotoxin. Its role in viral replication is already well known. Intensive research over the past decade has shown the involvement of this protein in many cellular activities both in ‘expressed’ a...
متن کاملRotavirus NSP4 protein as a viral biotoxin selectively promotes cytotoxicity
Abstract Background and Aims: The number of new cancer cases with considerable mortality is increasing worldwide. Since the inability of current therapies in treatment of patients and prevention the progress of tumors with fewer side effects, implementation of new methods is needed. Gene therapy has widespread systemic cytotoxic effects against tumor cells. Rotavirus NSP4 has been shown to...
متن کاملHigher Expression Level and Lower Toxicity of Genetically Spliced Rotavirus NSP4 in Comparison to the Full-Length Protein in E. coli
Background: Rotavirus group A (RVA) is recognized as a major cause of severe gastroenteritis in children and new-born animals. Nonstructural protein 4 (NSP4) is responsible for the enterotoxic activity of these viruses in the villus epithelial cells. Amino acids 114-135 of NSP4 are known to form the diarrhea-inducing region of this viral enterotoxin. Therefore, developing an NSP4 lacking the en...
متن کاملMolecular characterization of the rotavirus enterotoxin NSP4 gene of strains causing diarrhoea in children aged 0-5 years in northern India
Article history: Received on: 19/08/2015 Revised on: 03/09/2015 Accepted on: 30/09/2015 Available online: 27/11/2015 Non structural protein 4 (NSP4) gene of Rotavirus encodes a multifunctional protein which has significant role in viral multiplication and pathogenesis of acute watery diarrhoea associated with rotaviral gastroenteritis. It is known as the first viral enterotoxin and mutations of...
متن کاملrotavirus nsp4 protein as a viral biotoxin selectively promotes cytotoxicity running title: nsp4 protein as a viral biotoxin
objective: the number of new cancer cases with considerable mortality is increasing worldwide. since the inability of current therapies in treatment of patients and prevention the progress of tumors with fewer side effects, implementation of new methods is needed. gene therapy has widespread systemic cytotoxic effects against tumor cells. rotavirus nsp4 has been shown to elicit extensive cytoto...
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ژورنال
عنوان ژورنال: Journal of Applied Pharmaceutical Science
سال: 2015
ISSN: 2231-3354
DOI: 10.7324/japs.2015.50723